NAD+ — The Central Metabolic Coenzyme
Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme in hundreds of metabolic reactions and a substrate for enzymes governing DNA repair, gene expression, and cellular stress responses. Research focus sharpened after its identification as a sirtuin substrate, connecting it directly to longevity biology.
⚠️ Research Use Only
All products sold by FenaLife are intended strictly for laboratory and academic research purposes. Not for human consumption, injection, or ingestion. These statements have not been evaluated by the FDA.
NAD+-Consuming Enzyme Systems
Sirtuins (SIRT1–7)
NAD+-dependent deacetylases linked to longevity. SIRT1 regulates metabolism; SIRT3 manages mitochondrial ROS; SIRT6 is involved in DNA repair and genomic stability.
PARP Enzymes
Detect DNA strand breaks and facilitate repair. PARP1 can consume enormous quantities of NAD+ following DNA damage, potentially depleting cellular stores.
CD38 Ectoenzyme
Major driver of age-related NAD+ decline in rodent studies. CD38 inhibition research aims to preserve NAD+ levels in aging models.
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Energy Metabolism
Electron carrier in glycolysis, Krebs cycle, and oxidative phosphorylation — fundamental to ATP synthesis in every living cell.
Age-Related NAD+ Decline — Rodent Model Data (% of Young Animal Levels)
Skeletal Muscle~55% decline in aged mice
Adipose Tissue~60% decline
Liver~45% decline
Heart~50% decline
Brain~40% decline
Key Milestones in NAD+ Research
1906
Harden & Young discover cozymase (precursor to NAD+) in yeast fermentation extracts
1936
Warburg & Christian identify NAD+ as a hydride acceptor in cellular respiration
2000
Guarente lab links Sir2 (yeast sirtuin) to lifespan extension — launching the NAD+/longevity field
2013
Gomes et al. (Cell) document age-related NAD+ decline in mice and restoration with NMN
2016
First human clinical trials with NR (nicotinamide riboside) establish safety profile
⚠️ NAD+ Stability Considerations
Unlike most research peptides, NAD+ in solution is susceptible to hydrolysis — particularly at non-neutral pH. Use freshly reconstituted solutions. Store lyophilized NAD+ at −20°C, protected from light, moisture, and air.
FenaLife supplies research-grade NAD+ 500mg.
Conclusion
NAD+ connects energy metabolism, DNA repair, aging biology, and longevity research in a single molecule. Researchers studying cellular aging return to it repeatedly for that reason.
⚠️ Research Use Only
All products sold by FenaLife are intended strictly for laboratory and academic research purposes. Not for human consumption, injection, or ingestion. These statements have not been evaluated by the FDA.
Source NAD+ 500mg at FenaLife
Research-grade, HPLC-verified purity. Fast shipping.