Selank Research Guide: Anxiolytic Peptide Mechanisms and Cognitive Neuroscience

What Is Selank?

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analogue of the immunopeptide tuftsin, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Its mechanism centers on GABA-A modulation and BDNF pathway activation.

⚠️ Research Use Only
All products sold by FenaLife are intended strictly for laboratory and academic research purposes. Not for human consumption, injection, or ingestion. These statements have not been evaluated by the FDA.
Selank Profile
Property Value
Sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro
Parent Peptide Tuftsin (Thr-Lys-Pro-Arg)
Molecular Weight 751.9 g/mol
Key Mechanism GABA-A modulation, BDNF upregulation, immunomodulation
Selank Neurobiological Mechanisms
GABA-A Modulation
Enhances GABAergic transmission through a different binding site than benzodiazepines – without sedative or amnestic profile in research models.
BDNF Upregulation
Documented increased BDNF expression in animal models – relevant to neuroplasticity, learning, and hippocampal neurogenesis research.
Monoamine Modulation
Increased dopamine metabolism in frontal cortex; serotonin turnover effects in specific brain regions.
Immunomodulation
As a tuftsin analogue, studies show effects on IL-6, TNF-alpha, T-cell activity, and interferon-gamma expression.
Selank Preclinical Anxiolytic Evidence
Elevated plus mazePrimary model – strong evidence
Open field testWell-documented effects
Chronic stress modelsHPA axis modulation
Light-dark boxSupporting evidence
Selank vs Semax Comparison
Research Area Selank Semax
Primary mechanism GABA-A + BDNF BDNF + NGF
Anxiolytic effects Strong – primary application Limited
Neuroprotection Moderate Strong (ischemia models)
Stimulatory profile Low Moderate
Selank Storage and Reconstitution
1
Store at -20 degrees C
Protect from light.
2
Reconstitute with BAC water
Slowly against vial wall. Swirl gently.
3
Store at 2-8 degrees C
Use within 28 days.

FenaLife supplies Selank 10mg.

Conclusion

Selank’s dual action on GABA-A and BDNF pathways sets it apart from conventional anxiolytic research compounds. Explore FenaLife’s cognitive research peptides.

⚠️ Research Use Only
All products sold by FenaLife are intended strictly for laboratory and academic research purposes. Not for human consumption, injection, or ingestion. These statements have not been evaluated by the FDA.

Source Selank 10mg at FenaLife

Research-grade, HPLC-verified purity. Fast shipping.

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