Overview
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide and potent agonist of the growth hormone secretagogue receptor (GHSR-1a). It is one of the most extensively researched GHRPs, valued in laboratory settings for its reliable ability to stimulate pulsatile GH release from the anterior pituitary with minimal appetite-stimulating side effects compared to GHRP-6. GHRP-2 acts synergistically with GHRH analogues such as CJC-1295 or Sermorelin, a pairing frequently used in research protocols designed to amplify GH output. FenaLife supplies GHRP-2 for laboratory research use only.
Research Background
GHRP-2 was developed in the 1980s and 1990s during a period of intense research into synthetic GH secretagogues. It demonstrated potent GH-releasing activity in early clinical studies and has since been evaluated for applications in GH deficiency, sarcopenia, wound healing, and metabolic research. GHRP-2 produces GH peaks approximately 2-3 times above baseline in research subjects and is considered more potent on a molar basis than GHRP-6. Unlike GHRP-6, GHRP-2 produces less pronounced appetite stimulation, making it preferable in research contexts where appetite effects are a confounding variable.
Studied Mechanisms
GHRP-2 binds GHSR-1a receptors located in the hypothalamus and pituitary. Receptor activation stimulates pituitary somatotrophs to release GH in a pulsatile fashion while simultaneously modulating hypothalamic input — increasing GHRH output and transiently reducing somatostatin inhibition. The result is a robust but physiologically patterned GH pulse. GHRP-2 also has weak binding affinity for GHSR-1b, a truncated splice variant, though functional effects from this interaction are less defined in research literature. Downstream GH secretion drives IGF-1 synthesis in the liver, mediating anabolic effects on muscle, bone, and connective tissue.
Molecular Profile
Type: Synthetic hexapeptide. Sequence: D-Ala-D-βNal-Ala-Trp-D-Phe-Lys-NH2. Target: GHSR-1a. Molecular formula: C45H55N9O6. Molecular weight: 817.99 g/mol. Purity: ≥98% by HPLC.
Storage and Handling
Store lyophilized GHRP-2 at -20°C, protected from light and moisture. Reconstitute with bacteriostatic water. Store reconstituted solution at 4°C and use within 4 to 6 weeks. Avoid repeated freeze-thaw cycles.
Research Use Only
For laboratory research purposes only. Not for human or veterinary use. Certificate of Analysis available per batch.
🔬 Research Compounds Referenced: BAC Water 10ml