Introduction to IGF-1 LR3
IGF-1 LR3 carries two modifications over native IGF-1: a 13-amino acid N-terminal extension and an arginine substitution at position 3. Together they sharply reduce IGF-binding protein (IGFBP) affinity, stretching half-life from ~10 minutes to ~20-30 hours.
⚠️ Research Use Only
All products sold by FenaLife are intended strictly for laboratory and academic research purposes. Not for human consumption, injection, or ingestion. These statements have not been evaluated by the FDA.
IGF-1R Downstream Signalling
PI3K/Akt/mTOR
Primary anabolic and cell survival pathway. mTOR activation drives protein synthesis – central to muscle hypertrophy and cancer metabolism research.
MAPK/ERK Pathway
Cell proliferation and differentiation – key in cancer biology and growth factor signalling studies.
Insulin Receptor Cross-talk
IGF-1R shares ~70% homology with insulin receptor – relevant for metabolic research design.
The IGFBP Problem in Cell Culture
Native IGF-1 in serum-containing media is rapidly bound by IGFBPs, reducing effective concentration unpredictably. IGF-1 LR3 IGFBP resistance gives more reliable, reproducible results – making it the preferred research form.
IGF-1 LR3 Research Applications
Cell culture biologyPrimary – most published use
Cancer biologyIGF-1R overexpression in many cancers
Muscle biology / sarcopeniaGH-IGF axis studies
Bone metabolismOsteoblast and fracture models
Metabolic researchGlucose uptake, insulin sensitivity
IGF-1 LR3 Handling Protocol
1
Store at -80 degrees C (preferred) or -20 degrees C
More temperature-sensitive than most peptides.
2
Reconstitute in 0.1% acetic acid initially
Acidic initial reconstitution required for complete dissolution. Then dilute in PBS.
3
Aliquot to avoid freeze-thaw
Divide into single-use aliquots.
4
Validate concentration for your cell type
Requirements vary by cell type – review published literature.
FenaLife supplies IGF-1 LR3 1mg.
Conclusion
IGF-1 LR3 is the standard IGF-1 analogue for cell culture, muscle, cancer, bone, and metabolic research. Its extended half-life and IGFBP resistance make it more tractable than native IGF-1 across all those contexts.
⚠️ Research Use Only
All products sold by FenaLife are intended strictly for laboratory and academic research purposes. Not for human consumption, injection, or ingestion. These statements have not been evaluated by the FDA.
Source IGF-1 LR3 1mg at FenaLife
Research-grade, HPLC-verified purity. Fast shipping.