Introduction to KPV
KPV (Lysine-Proline-Valine) maps to the C-terminal sequence of alpha-MSH. Research shows it retains strong anti-inflammatory potency, with better stability than the full 13-amino acid peptide in targeted applications.
⚠️ Research Use Only
All products sold by FenaLife are intended strictly for laboratory and academic research purposes. Not for human consumption, injection, or ingestion. These statements have not been evaluated by the FDA.
KPV Anti-Inflammatory Mechanisms
Melanocortin Receptor Agonism
Acts at MC1R, MC3R, MC4R on immune cells and intestinal epithelial cells, driving anti-inflammatory signalling.
NF-kB Pathway Inhibition
Studies show KPV reduces nuclear translocation of NF-kB — a central transcription factor controlling inflammatory gene expression.
Direct Cellular Entry
Research demonstrates KPV can enter cells directly via organic cation transporters — providing intracellular activity.
Cytokine Reduction
Documented reduction of TNF-alpha, IL-1beta, and IL-6 in stimulated cell and animal models.
KPV GI Research Evidence by Model Type
DSS-induced colitis (rodent)Most extensively studied
TNBS-induced colitisStrong evidence base
Intestinal epithelial barrier studiesTight junction research
Oral nanoparticle deliveryTargeted gut delivery systems
KPV Storage and Reconstitution
1
Store lyophilized at −20°C
Stable. Protect from light and humidity.
2
Reconstitute with sterile or BAC water
Water-soluble. Add slowly against vial wall.
3
Store reconstituted at 2–8°C
Use within 28 days in BAC water.
FenaLife supplies KPV 10mg.
Conclusion
KPV inhibits NF-kB and enters cells directly via organic cation transporters, giving it a mechanism distinct from most anti-inflammatory research tools. Researchers studying gut inflammation find it especially applicable. Explore FenaLife’s immune research peptides.
⚠️ Research Use Only
All products sold by FenaLife are intended strictly for laboratory and academic research purposes. Not for human consumption, injection, or ingestion. These statements have not been evaluated by the FDA.