Overview
Argireline (acetyl hexapeptide-3) is a synthetic hexapeptide cosmetic research compound designed to mimic the N-terminal region of SNAP-25 and interfere with SNARE complex assembly at neuromuscular junctions. It is one of the most studied cosmetic peptides in dermatological research and is used as a reference compound in SNARE modulation and transdermal peptide delivery studies. FenaLife supplies Argireline for research use only.
Research Background
Argireline was the first SNARE-modulating cosmetic peptide to be developed and has been subject to multiple in vitro and topical efficacy studies. Published research has documented inhibition of SNARE complex formation, reduced catecholamine release in neuronal cell models, and reductions in periocular wrinkle depth in human topical application studies. It serves as the reference compound for the SNAP-8 and related cosmetic peptide class.
Studied Mechanisms
Argireline’s hexapeptide sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) competes with SNAP-25 for binding partners in the SNARE complex, reducing vesicle fusion efficiency and acetylcholine release intensity at neuromuscular junctions in topically treated areas. The magnitude of effect is moderate and local, consistent with the limited transdermal penetration achievable with unmodified peptide delivery.
Molecular Profile
Molecular formula: C34H60N12O10. Molecular weight: 888.93 g/mol. Purity: ≥98% by HPLC. Water-soluble; dissolves readily in aqueous formulations.
Storage and Handling
Store lyophilized Argireline at -20°C, protected from light. Reconstitute with bacteriostatic water. Store reconstituted solution at 4°C and use within 4 to 6 weeks.
Research Use Only
For laboratory research purposes only. Not for human or veterinary use. Certificate of Analysis available per batch.